Product Education: Joints

What are Joints?

Joints form the connections between bones. They provide support and allow your body to move. Any damage to the joints from disease or injury can interfere with your movement, cause discomfort and stiffness.

What Causes Joint Pain?

Many different conditions can lead to painful joints, including osteoarthritis, rheumatoid arthritis, bursitis, gout, strains, sprains, and other injuries. Joint pain is extremely common. In one national survey, about one-third of adults reported having joint pain within the past 30 days. Knee pain was the most common complaint, followed by shoulder and hip pain, but joint pain can affect any part of your body, from your ankles and feet to your shoulders and hands. As you get older, painful joints become increasingly more common.

Other common benefits people report:

• Reduces discomfort
• Increases mobility
• Helps to balance whole body inflammation
• Promotes health
• Increases energy
• Improves repair
• Easier to turn your head when reversing your car
• Easier to lift arms above head
• Easier to turn over in bed at night
• Improved sleep

Cyactiv Joint Ingredients

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Backed by Science

Each ingredient has been clinically tested at the doses provided in Cyactiv Joint. Cyactiv Joint is formulated to nourish and support cartilage, joints, muscles, and connective tissue. The formula contains compounds that modulate inflammatory enzymes and powerful antioxidant phenolic compounds that reduce muscle fatigue and muscle damage.

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Our Point of Difference

Our cutting-edge products are backed by science

Our flagship products have been studied in multiple third-party independent clinical trials that document their health benefits. Our Research & Development team has pioneered many advancements in nutritional science, including the revolutionary discovery and development of the world's first stem cell enhancer: StemEnhance*. We hold several patents on StemEnhance*, which remains the most studied and clinically proven stem cell support product on the market and is only available through Cerule.

Research & Development (R&D) Team

Led by world-renowned scientist and research consultant Dr. Gitte Jensen, Cerule's R&D team has earned global recognition for its significant contributions in many areas of nutraceutical science. R&D oversees the development and formulation of our premium-quality products and is responsible for keeping Cerule on the cutting-edge of scientific advancements. R&D also prepares and oversees all clinical trials conducted to document and prove the efficacy of Cerule's products.

Total control process = better quality products for you

Cerule currently manufactures three key ingredients, StemEnhance, Cyactiv, and Mesenkine, that constitute the core of two of its three signature products. This means that Cerule controls the process every step of the way, ensuring the premium quality that consumers have come to expect and trust. The ingredients we do not grow or harvest ourselves come from the industry's most reputable, GMP-certified companies. All ingredients, including Cerule's own, undergo rigorous quality testing in-house with third-party verification. The ingredients in all of our products are guaranteed for their purity and safety.

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REFERENCES

Spirulina extract

Jensen G., Attridge V., Beaman J., Guthrie J., Ehmann A., Benson K., 2015, Antioxidant and anti-inflammatory properties of an aqueous cyanophyta extract derived from Arthrospira platensis: contribution to bioactivities by the non phycocyanin aqueous fraction, Journal of Medicinal Food, 18(5):535-541.

Jensen G., Attridge V., Carter S., Guthrie J., Ehmann A., Benson K., 2016, Consumption of an aqueous cyanophyta extract derived from Arthrospira platensis is associated with reduction of chronic pain: results from two human clinical pilot studies, Nutrition and Dietary Supplements, 8:65-70.

Jensen G., Drapeau C., Lenninger M., Benson K., 2016, Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation, Journal of Medicinal Food, 19(7): 1-9.

Eggshell membrane

Benson K., Ruff K., Jensen G., 2012, Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In-Vitro Digestion, J Med Food 15 (4) 2012, 360–368

Ruff K., DeVore D., Leu M., Robinson M., 2009, Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two openlabel human clinical studies, Clinical Interventions in Aging 2009:4 235–240.

Danesch U., Seybold M., et al., 2014, NEM® Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study, J Arthritis, 3(3):1-5.

Ruff K., Winkler A., Jackson R. et al., 2009, Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double blind, placebo-controlled clinical study, Clin Rheumatol, 28:907–914.

Tart Cherry powder

Connolly D., McHugh M., Padilla-Zakour O., 2006, Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage, Br J Sports Med 2006;40:679–683.

Levers K., Dalton R., Galvan E., O’Connor A., et al., 2016, Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals, Journal of the International Society of Sports Nutrition, 13:22

Boswellia serrata extract

Kimmatkar N., Thawani V., Hingorani L., Khiyani R., 2003, Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial, Phytomedicine, 10(1):3-7

Prabhavathi K., Chandra U., Soanker R., Rani P., 2014, A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model, Indian J. Pharmacol, 46(5):475-479.

Umar S., Umar K., Sarwar A., et al., 2014, Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis, Phytomedicine, 21(6):847-56.https://www.ncbi.nlm.nih.gov/pubmed/24667331